Associate Director, Portfolio Project Management

At Bicycle, we benefit from a hybrid style working arrangement, allowing employees where possible the opportunity to collaborate and engage with their coworkers in person while also benefiting from the flexibility of remote working. A typical hybrid arrangement for this role is 3 days onsite per week at our Cambridge, UK office, with the remainder of your working week remote.

Your mission is to serve as the operational engine of our cross-functional pipeline, seamlessly bridging Research & Innovation (R&I) and Clinical Development. Working under the guidance of the VP, Portfolio Strategy & Scientific Affairs and our Director-level project management leadership, you will oversee the day-to-day coordination, tracking, and operational management of our therapeutic portfolio. By maintaining highly accurate integrated Gantt charts, orchestrating clear meeting agendas, capturing precise action-oriented minutes, and tracking project interdependencies across departments, you will enable our scientific and clinical teams to execute seamlessly, mitigate risks, and deliver the next wave of novel Bicycle® therapeutics on time and within budget.

Portfolio Tracking, Planning & Operational Excellence

• Master Timeline & Gantt Chart Management: Create, maintain, and continuously optimize integrated master project plans and detailed Gantt charts across both Research & Innovation (R&I) and Clinical programs, identifying critical paths and key interdependencies.
• Meeting Administration & Governance Support: Coordinate and administer project team meetings. This includes driving the preparation of collaborative, objective-focused agendas, capturing high-quality, action-oriented minutes, and systematically tracking follow-up deliverables to closure.
• Portfolio Dashboards & Reporting: Maintain portfolio-level tracking tools, dashboards, and risk registries under the guidance of Director leadership to provide senior stakeholders with high-visibility, real-time access to program statuses.
• Documentation & Repository Stewardship: Ensure all project-related documentation, decision logs, and collaboration portals (e.g., SharePoint, MS Teams) are meticulously organized, up-to-date, and standardized across R&I and Clinical teams.
• Publications Support: Support publications tracking, timelines and maintaining a publications repository across R&I and Clinical.

Pipeline Delivery & Operational Execution

• Cross-Functional Execution: Collaborate with team members across nonclinical, translational, clinical, regulatory, and CMC functions to ensure that project objectives and milestones leading to IND/CTA filings and clinical trial milestones are executed within scope and budget.
• Resource & Timeline Optimization: Proactively identify timeline variances, operational inefficiencies, and resource bottlenecks, escalating them with constructive mitigation recommendations to project leaders and Director-level sponsors.
• Risk Tracking & Mitigation: Facilitate risk identification workshops/discussions at the project team level, capturing risks within the project risk register and tracking the execution of agreed-upon mitigation plans.

Stakeholder Engagement & Business Partnership

• Operational Business Partnering: Act as a reliable operational partner to R&I and Clinical Project Leaders, helping to translate complex scientific and clinical strategies into tangible, trackable plans.
• Functional Alignment & Communication: Foster clear, proactive, and transparent communication across functions, bridging communication gaps and ensuring that interdependencies are visible and managed.
• External Partner Coordination: Assist in managing PM activities for alliance partnerships, CROs, and external scientific collaborations, ensuring meeting agendas, minutes, and deliverables are aligned with contract milestones.