Principal Technical Project Manager ( we have office locations in Cambridge, Leeds & London)

We are seeking a Principal Technical Project Manager to help deliver and enhance modern on-premise and cloud-based infrastructure supporting world-leading genomics diagnostics and research. In this role, you will work closely with the Scalable Service Lead and leadership team to guide multiple interdependent technical workstreams, ensuring delivery aligns with programme objectives, governance frameworks, and PMO standards.
You will collaborate across squads, suppliers, and partners, while supporting the Service Owner in coordinating technical platform delivery and managing third-party contributions. This senior role suits someone with strong technical understanding, excellent stakeholder engagement skills, and experience delivering complex platforms in regulated or data-intensive environments, with a collaborative and inclusive approach to delivery.

Everyday responsibilities include:

• Lead end-to-end delivery of key technical areas within the programme, taking ownership while fostering a collaborative, supportive delivery environment.
• Partner with the Product Manager and/or Service Owner to validate and agree requirements, ensuring alignment with timelines, budgets, and OKRs.
• Establish and maintain delivery plans, tracking progress and communicating clearly where adjustments or support are needed.
• Proactively identify and resolve issues, working closely with teams to remove blockers and enable successful outcomes.
• Create and manage RAID (Risks, Actions, Issues, and Dependencies) logs, regularly reviewing and coordinating follow-up actions.
• Produce clear, concise status updates and contribute to programme and board-level reporting where required.
• Support structured and inclusive decision-making processes, ensuring the right stakeholders are engaged at the right time.
• Apply appropriate governance to meet internal and external standards, including cybersecurity, data protection, data quality, and regulatory requirements.
• Ensure transparent, thoughtful communication so delivery teams understand priorities, timelines, and expectations, while keeping stakeholders informed.
• Build positive relationships with internal and external stakeholders, managing escalations. constructively and facilitating respectful conflict resolution when needed.

Skills and experience for success:

• Project, risk, and issue management with a proactive and solutions-focused approach.
• Strong communication skills, engaging effectively with both technical and non-technical audiences.
• Commercial awareness and financial understanding to support informed decision-making.
• Stakeholder management, building trusted relationships across teams and leadership levels.
• Confident decision-making with sound judgement on escalation and risk management.
• Ability to translate complex technical concepts into clear, accessible language for non-technical stakeholders.
• Collaborative approach to problem-solving, balancing delivery priorities with business needs.

Exposure of the following technologies:

• AWS ecosystem, including core infrastructure services such as EC2, S3, RDS and IAM.
• Understanding of AWS architecture tools and services such as Lambda, EKS, VPC and Direct Connect.
• Experience or awareness of operational and infrastructure-as-code tools including CloudFormation, Terraform and CloudWatch.
• Exposure to AWS data and analytics services such as Glue, Redshift and Step Functions.