Principal Technical Project Manager (we have office locations in Cambridge, Leeds & London)

Genomics England is delivering a new, modern Research Environment (RE3) to support world-leading genomics research and is seeking a Principal Technical Project Manager to lead complex technical initiatives within the programme.

Working with the RE3 Programme Manager, you will oversee multiple interdependent workstreams, ensuring delivery aligns with programme objectives, governance, and PMO standards while coordinating activity across squads, suppliers, and partners.

The role includes ongoing management of technical components, providing delivery support to the Service Owner, and overseeing cross-squad activity, third-party suppliers, and platform integration.

This senior position requires strong technical expertise, stakeholder engagement skills, experience delivering complex platforms in regulated or data-intensive environments and may include line management responsibilities.

Everyday responsibilities include:

• Own end-to-end delivery of key technical workstreams, taking accountability for scope, timelines, and outcomes.
• Validate and agree requirements with the Product Manager and/or Service Owner to ensure delivery against timelines, budgets, and OKRs.
• Establish, maintain, and track delivery plans, escalating risks and deviations where necessary.
• Create and actively manage RAID logs (Risks, Actions, Issues, Dependencies) to support proactive delivery management.
• Produce regular status reports and contribute to programme and governance board updates.
• Implement appropriate governance to ensure compliance with cybersecurity, data protection, and regulatory standards.
• Coordinate cross-team delivery, supporting issue resolution and driving decision-making where uncertainty exists.
• Manage communication across squads, suppliers, and stakeholders, including escalation to senior leadership when required.
• Oversee third-party suppliers and procurement activities, ensuring alignment with governance and approved budgets.
• Provide leadership within the delivery function, including mentoring contributors and supporting line management and best-practice adoption.

Skills and experience for success:

• Extensive experience leading large-scale, complex technical projects within life sciences, healthcare, research, or public sector organisations.
• Strong understanding of the software development.
• Excellent communication skills, with the ability to engage effectively across technical and non-technical audiences.
• Strong stakeholder management skills with the ability to plan, prioritise, and escalate appropriately.
• Good commercial and financial acumen, including budget awareness and supplier engagement.
• Demonstrable knowledge of AWS and cloud architectures, with the ability to translate technical requirements and issues for non-technical stakeholders.

Desirable skills:

• Strong knowledge of AWS ecosystem services, including EC2, S3, RDS, IAM, Lambda, EKS, VPC, and Direct Connect.
• Familiarity with Terraform, Kubernetes, CI/CD pipelines, test-driven development, database technologies, and Agile delivery (Scrum and/or Kanban).