Research Scientist II/Sr, Analytical Purification

JOB SUMMARY

We are seeking a highly skilled and motivated Analytical/Bioanalytical Scientist with a strong focus on chromatography-based purification to join our drug discovery team. The successful candidate will play a key role in supporting high throughput purification and assay workflow to enable weekly design-make-test-analysis workflow supporting in house AI based drug discovery engine. The ideal candidate will have extensive experience in chromatographic purification, particularly SFC and/or LC purification of small molecules, along with proven skills in instrument troubleshooting, workflow optimization, and a working understanding of ADME/DMPK assay design and execution.

KEY RESPONSIBILITIES

• Serve as the expert for chromatography-based purification, with deep experience in SFC and LC-based purification of small molecules in a drug discovery environment.

• Develop, implement, and optimize purification workflows, including preparative chromatography methods, fraction collection strategies, and post-purification data integration

• Design and maintain automated purification workflows to increase throughput, reproducibility, and sample quality

• Collaborate with medicinal chemistry, purification, and DMPK teams to deliver high-quality purified compounds to support lead optimization and screening.

• Provide hands-on support, preventive maintenance, and troubleshooting for LC, LC/MS, and SFC instruments, to minimize downtime and ensure consistent lab operations.

• Partner with vendors and automation providers for service, upgrades, installations, and workflow integration

• Potential support ADME/DMPK and physicochemical assays, contributing to method development, troubleshooting, and execution as needed

• Document purification workflows, maintenance activities, and troubleshooting in compliance with laboratory best practices

QUALIFICATIONS

• Advanced degree (M.S. with or Ph.D.) in Analytical Chemistry, Chemistry, Chemical Engineering, or related field; or equivalent industry experience

• Minimum of Ph.D and 2 years of experience OR M.S with 6 years of experience

• Extensive hands-on experience in chromatography-based purification, with deep expertise in SFC and/or LC purification of small molecules

• Strong experience operating, maintaining, and troubleshooting LC, LC/MS, and SFC systems (Shimadzu, Agilent, Sciex, preferred)

• Proven ability to diagnose and resolve common instrument and workflow issues

• Familiarity with informatics tools such as Virscidian, Pipeline Pilot, KNIME, or equivalent for purification data management

• Experience developing and supporting ADME/DMPK and physicochemical assays is a strong plus

• Solid understanding of the drug discovery process from lead identification through candidate optimization

• Excellent organizational, communication, and documentation skills.

• Ability to work both independently and collaboratively in a dynamic, cross-functional research environment

ABOUT IAMBIC THERAPEUTICS

Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.

MISSION & CORE VALUES

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

PAY AND BENEFITS

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.